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Tolerance in the context of addiction refers to the phenomenon where an individual requires increasing amounts of a substance to achieve the same effect that was previously attained with lesser amounts. This is a significant aspect of substance use disorders, as it indicates an adaptation of the brain and body to the presence of the substance, diminishing its effects over time.

As a person continues to use a substance, the body may become less responsive to its effects due to various physiological changes, leading to the need for higher doses to experience the desired high or relief. This increase in consumption can escalate the cycle of use, leading to greater dependency and potential for addiction-related problems.

While craving for the substance, experiencing physical withdrawal symptoms, and developing psychological dependence are all critical components of addiction, they do not specifically define the concept of tolerance. Tolerance is uniquely characterized by the need for more significant amounts to achieve prior effects, distinguishing it from other aspects of substance use and addiction.